Abstract #0912
Effect of pantethine on ovarian tumor progression and choline metabolism
Marie-France Penet 1 , Delia Mezzanzanica 2 , Franca Podo 3 , Max de Reggi 4 , Bouchra Gharib 4 , and Zaver M. Bhujwalla 1
1
JHU ICMIC Program, Division of Cancer
Imaging Research, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States,
2
Unit
of Molecular Therapies, Department of Experimental
Oncology and Molecular Medicine, Fondazione IRCCS
Istituto Nazionale dei Tumori, Milan, Italy,
3
Department
of Cell Biology and Neurosciences, Section of Molecular
and Cellular Imaging, Istituto Superiore di Sanit,
Rome, Italy,
4
Neurobiology
of Cellular Interactions and Neuropathophysiology, UMR
CNRS 7259, Aix-Marseille University, Marseille, France
Epithelial ovarian cancer remains the leading cause of
death from gynecologic malignancy among women in
developed countries. New therapeutic strategies
evaluated with relevant preclinical models are urgently
needed to improve survival rates. Here we have assessed
the effect of pantethine on tumor growth and metabolism
using MRI and high resolution MRS, respectively, in an
orthotopic model of ovarian cancer. We also investigated
effects on metastases and ascites formation. Pantethine
treatment resulted in slower tumor progression,
decreased levels of phosphocholine and
phosphatidylcholine, and reduced metastases and ascites
occurrence.
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