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Abstract #0912

Effect of pantethine on ovarian tumor progression and choline metabolism

Marie-France Penet 1 , Delia Mezzanzanica 2 , Franca Podo 3 , Max de Reggi 4 , Bouchra Gharib 4 , and Zaver M. Bhujwalla 1

1 JHU ICMIC Program, Division of Cancer Imaging Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 Unit of Molecular Therapies, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, 3 Department of Cell Biology and Neurosciences, Section of Molecular and Cellular Imaging, Istituto Superiore di Sanit, Rome, Italy, 4 Neurobiology of Cellular Interactions and Neuropathophysiology, UMR CNRS 7259, Aix-Marseille University, Marseille, France

Epithelial ovarian cancer remains the leading cause of death from gynecologic malignancy among women in developed countries. New therapeutic strategies evaluated with relevant preclinical models are urgently needed to improve survival rates. Here we have assessed the effect of pantethine on tumor growth and metabolism using MRI and high resolution MRS, respectively, in an orthotopic model of ovarian cancer. We also investigated effects on metastases and ascites formation. Pantethine treatment resulted in slower tumor progression, decreased levels of phosphocholine and phosphatidylcholine, and reduced metastases and ascites occurrence.

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