Abstract #0911
Global and regional brain concentration of intra- and extra- cellular sodium in MS: a 7 Tesla MRI study
Matilde Inglese 1 , Maria Petracca 1 , Roxana Teodorescu 2 , Laura Jonkman 2 , Niels Oesingmann 3 , and Lazar Fleysher 4
1
Neurology, Icahn School of Medicine at Mount
Sinai, New York, New York, United States,
2
Icahn
School of Medicine at Mount Sinai, New York, New York,
United States,
3
Siemens
Healthcare, New York, New York, United States,
4
Radiology,
Icahn School of Medicine at Mount Sinai, New York, New
York, United States
Accumulation of intra-axonal sodium ions represents a
key factor in the degenerative process in multiple
sclerosis (MS). MRI measurement of total sodium
concentration (TSC) is feasible in MS patients. We
report the in-vivo measurement at 7 Tesla MRI of intra
and extracellular sodium concentrations in MS patients.
We describe the potential contribution of sodium
dishomeostasis to disease pathophysiology and its
clinical impact.
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