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Abstract #0913

Acquired resistance to sunitinib is not associated with rescue angiogenesis in 786-O renal cell carcinoma xenografts

Simon P Robinson 1 , Naveen S Vasudev 2 , and Andrew R Reynolds 2

1 Division of Radiotherapy & Imaging, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom

The response of 786-O RCC xenografts to sunitinib was investigated using susceptibility contrast MRI with USPIO particles. Fractional blood volume (fBV) was significantly reduced after 2 weeks daily treatment in the absence of any change in tumour volume. This reduced fBV was maintained in 786-O xenografts exhibiting acquired resistance to sunitinib.

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