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Abstract #0834

Brain iron accumulation in first episode of mania

Vanessa Wiggermann 1,2 , Enedino Hernndez Torres 1,3 , Leonardo E. da Silveira 4 , Lakshmi N. Yatham 4 , and Alexander Rauscher 1,3

1 Radiology, University of British Columbia, Vancouver, BC, Canada, 2 Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 3 UBC MRI Research Centre, Vancouver, BC, Canada, 4 Psychiatry, University of British Columbia, Vancouver, BC, Canada

Many psychiatric disorders are suggested to relate to metabolite changes and oxidative stress, which may be associated with iron accumulation in the brain. Here, we used susceptibility-sensitive gradient echo imaging to compare MR resonance frequency shifts and R2* relaxation rates in the deep brain gray matter between first episode mania patients and healthy controls. We found significant increases in MR resonance frequency in the caudate and the globus pallidus and a significant reduction in the ventral striatum in patients compared to controls. However, we observed no differences in R2* values between patients and healthy controls.

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