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Abstract #0835

Quantitative T1rho Mapping of Bipolar Disorder: Basal Differences in Euthymia

Casey P. Johnson 1 , Robin L. Follmer 2 , Ipek Oguz 3 , Lois A. Warren 2 , Gary E. Christensen 3 , Jess G. Fiedorowicz 2 , Vincent A. Magnotta 1,2 , and John A. Wemmie 2,4

1 Radiology, University of Iowa, Iowa City, IA, United States, 2 Psychiatry, University of Iowa, Iowa City, IA, United States, 3 Electrical and Computer Engineering, University of Iowa, Iowa City, IA, United States, 4 Veteran Affairs Hospital Center, Iowa City, IA, United States

We investigated the hypothesis that metabolism is abnormal in patients with bipolar disorder vs. normal controls using 3D quantitative T1ρ mapping. The T1ρ relaxation time has been shown to be sensitive to byproducts of metabolism including pH and metabolite concentrations. We observed that T1ρ is elevated in a euthymic case group, with evidence for a whole-brain difference as well as focal changes that exceed the global effect. This study furthers our understanding of bipolar disorder, identifies regions of interest to probe in future studies, and establishes T1ρ as a potential marker for abnormal metabolism in psychiatric diseases.

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