Abstract #0807
Plasma Metabolomics in Childhood Obesity using 1 H NMR
Hetty Prinsen 1 , Cosimo Giannini 2 , Robin A de Graaf 1 , Nicola Santoro 1 , Christoph Juchem 1 , Sonia Caprio 1 , and Raimund I Herzog 1
1
Yale University, New Haven, CT, United
States,
2
University
of Chieti, Chieti, Italy
The prevalence of obesity has increased to epidemic
levels, not only in adults, but also in children.
Obesity has been associated with the development of
insulin resistance, progression to type 2 diabetes,
development of fatty liver, and progression to liver
cirrhosis. We are still in need for sensitive biomarkers
that allow identification of the particularly at risk
individuals amenable to early and intensive
interventions. Here we correlate clinical markers of
obesity-related complications with plasma metabolite
levels in obese insulin-sensitive and insulin-resistant
youth, using a novel workflow for acquisition and
processing of metabolomic
1
H
NMR data.
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