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Abstract #0808

Chronic Hepatic Encephalopathy in the developing and adult rat brain: an in vivo non-invasive and longitudinal metabolic investigation using 1H MRS, DTI and immunohistochemistry

Veronika Rackayov 1 , Olivier Braissant 2 , Valrie A. McLin 3 , and Cristina Cudalbu 4

1 Laboratory for Functional and Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, 2 Laboratoire de Chimie Clinique, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Vaud, Switzerland, 3 Swiss Center for Liver Disease in Children, Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland, 4 Centre dImagerie Biomedicale (CIBM), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Vaud, Switzerland

Chronic liver disease affects both adults and children and is often associated with some degree of hepatic encephalopathy (HE). In childhood, acute hyperammonemia (HA) is associated with brain edema and leads to irreversible damage of the developing central nervous system (CNS). Although cognitive deficits exist in children with CLD, the underlying mechanism is unclear [2]. How the developing brain responds to the metabolic changes of CLD, and how these mechanisms differ from those in adult patients are two unknowns. We hypothesized that blood-brain-barrier permeability and energy metabolism may be different in adult and developing brain.

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