Abstract #0764
Amide Proton Transfer Imaging in Grading Diffuse Gliomas: Comparison with Contrast-enhanced and Diffusion-weighted MR Imaging
Osamu Togao 1 , Takashi Yoshiura 1 , Jochen Keupp 2 , Akio Hiwatashi 1 , Koji Yamashita 1 , Kazufumi Kikuchi 1 , Yuriko Suzuki 3 , Koji Sagiyama 4 , Masaya Takahashi 4 , and Hiroshi Honda 1
1
Clinical Radiology, Graduate School of
Medical Science, Kyushu University, Fukuoka, Fukuoka,
Japan,
2
Philips
Research Europe, Hamburg, Germany,
3
Philips
Electronics Japan, Tokyo, Japan,
4
Advanced
Imaging Research Center, UT Southwestern Medical Center,
Dallas, Texas, United States
APT imaging is a specific type of endogenous CEST
imaging technique. We reported that APT imaging
successfully predicted histopathological grades of
diffuse gliomas in patients. Since APT is a newly
developed technique, a further verification by comparing
with conventional MRI methods is required. In this
study, we assessed the diagnostic performance of APT
imaging for grading of diffuse gliomas by comparisons
with contrast-enhanced and diffusion-weighted imaging.
APT imaging showed high diagnostic performance to in
grading gliomas compared with contrast-enhanced and
diffusion-weighted imaging. APT has an additive value to
other MR methods and is useful in accurate glioma
grading.
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