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Abstract #0764

Amide Proton Transfer Imaging in Grading Diffuse Gliomas: Comparison with Contrast-enhanced and Diffusion-weighted MR Imaging

Osamu Togao 1 , Takashi Yoshiura 1 , Jochen Keupp 2 , Akio Hiwatashi 1 , Koji Yamashita 1 , Kazufumi Kikuchi 1 , Yuriko Suzuki 3 , Koji Sagiyama 4 , Masaya Takahashi 4 , and Hiroshi Honda 1

1 Clinical Radiology, Graduate School of Medical Science, Kyushu University, Fukuoka, Fukuoka, Japan, 2 Philips Research Europe, Hamburg, Germany, 3 Philips Electronics Japan, Tokyo, Japan, 4 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, United States

APT imaging is a specific type of endogenous CEST imaging technique. We reported that APT imaging successfully predicted histopathological grades of diffuse gliomas in patients. Since APT is a newly developed technique, a further verification by comparing with conventional MRI methods is required. In this study, we assessed the diagnostic performance of APT imaging for grading of diffuse gliomas by comparisons with contrast-enhanced and diffusion-weighted imaging. APT imaging showed high diagnostic performance to in grading gliomas compared with contrast-enhanced and diffusion-weighted imaging. APT has an additive value to other MR methods and is useful in accurate glioma grading.

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