Meeting Banner
Abstract #0763

Serial pH-weighted imaging using amide proton transfer in acute ischemic stroke

George William John Harston 1 , Yee Kai Tee 2 , Nicholas Blockley 3 , Thomas Okell 3 , Jacob Levman 2 , Fintan Sheerin 4 , Martino Cellerini 4 , Peter Jezzard 3 , Michael Chappell 2 , Stephen Payne 2 , and James Kennedy 1

1 Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Department of Engineering Science, University of Oxford, Oxford, Oxfordshire, United Kingdom, 3 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United Kingdom, 4 Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, United Kingdom

Measurement of amide proton transfer using chemical exchange saturation transfer techniques can be used to generate an intracellular pH-weighted image of the brain. In experimental models of cerebral ischemia pH is known to fall prior to irreversible infarction. Thus pH-weighted imaging may be useful to assess the metabolic state of potentially viable, but at risk, tissue during stroke, allowing a better understanding of disease processes within individual patients. These data demonstrate the natural history of pH-weighted imaging in patients with acute ischemic stroke and demonstrate different patterns of acidosis in reperfused and non-reperfused brain tissue.

This abstract and the presentation materials are available to members only; a login is required.

Join Here