Abstract #0763
Serial pH-weighted imaging using amide proton transfer in acute ischemic stroke
George William John Harston 1 , Yee Kai Tee 2 , Nicholas Blockley 3 , Thomas Okell 3 , Jacob Levman 2 , Fintan Sheerin 4 , Martino Cellerini 4 , Peter Jezzard 3 , Michael Chappell 2 , Stephen Payne 2 , and James Kennedy 1
1
Radcliffe Department of Medicine, University
of Oxford, Oxford, Oxfordshire, United Kingdom,
2
Department
of Engineering Science, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
3
Nuffield
Department of Clinical Neurosciences, University of
Oxford, Oxford, Oxfordshire, United Kingdom,
4
Oxford
University Hospitals NHS Trust, Oxford, Oxfordshire,
United Kingdom
Measurement of amide proton transfer using chemical
exchange saturation transfer techniques can be used to
generate an intracellular pH-weighted image of the
brain. In experimental models of cerebral ischemia pH is
known to fall prior to irreversible infarction. Thus
pH-weighted imaging may be useful to assess the
metabolic state of potentially viable, but at risk,
tissue during stroke, allowing a better understanding of
disease processes within individual patients. These data
demonstrate the natural history of pH-weighted imaging
in patients with acute ischemic stroke and demonstrate
different patterns of acidosis in reperfused and non-reperfused
brain tissue.
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