Abstract #0762
In Vivo Monitoring of Liver Glycogen by Chemical Exchange Saturation Transfer Imaging (GlycoCEST) in Live Mice
Koji Sagiyama 1 , Shanrong Zhang 1 , Ivan Dimitrov 1,2 , A. Dean Sherry 1 , and Masaya Takahashi 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Philips
Medical Systems, Cleveland, Ohio, United States
GlycoCEST imaging is one subset of the chemical exchange
saturation transfer (CEST) imaging methods which refers
specifically to detecting tissue glycogen, which may
enable investigation of both normal physiology and
various liver diseases. In the present study, we
performed phantom and in vivo glycoCEST imaging to
detect glycogen and to monitor temporal changes of
tissue glycogen concentration in the liver in mice
before and after fasting. Our results showed the
potential of glycoCEST to study glycogenolysis in vivo.
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