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Abstract #0765

MTC free APT and rNOE-CEST Images of Human Brain at 7T

Xiang Xu 1,2 , Nirbhay N. Yadav 1,2 , Craig K. Jones 1,2 , Haifeng Zeng 1,2 , Jinyuan Zhou 1,2 , Peter C. M. van Zijl 1,2 , and Jiadi Xu 1,2

1 Radiology Department, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

The Variable Delay Multi-Pulse (VDMP) CEST method can image slow exchange processes such as Amide Proton Transfer (APT) and exchange relayed Nuclear Overhauser Enhancement (rNOE) without the need for a full Z-spectrum by subtracting signals acquired at two pulse delays. Here we examine the use of the VDMP-CEST sequence to the human brain, where the inter-pulse delay is optimized to remove conventional magnetization transfer contrast (MTC), allowing MTC free APT and rNOE images to be obtained. The results show similar rNOE effects in gray and white matter, while APT effects are higher in gray matter than in white matter.

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