Abstract #0759
Deactivation of the default mode network is associated with resting-state glutamate and GABA
Yuzheng Hu 1 , Xi Chen 1 , Hong Gu 1 , and Yihong Yang 1
1
Neuroimaging Research Branch, National
Institute on Drug Abuse, NIH, Baltimore, MD, United
States
The default mode network (DMN) deactivation observed
with BOLD fMRI is thought to be associated with
suppression of spontaneous brain activities and
reallocation of resources to ongoing,
attention-demanding tasks. However, the underlying
neurochemical mechanism of DMN deactivation remains
largely unknown. The current study aimed to examine the
relationship between DMN deactivation induced by a WM
task and the endogenous concentrations of glutamate and
GABA in the posterior cingulate/precuneus region. The
major excitatory neurotransmitter, glutamate, was found
to prevent BOLD signal from deactivation while GABA, the
major inhibitory neurotransmitter, exert opposite
effects.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
