Abstract #0760
Imaging astrocyte reactivity using gluCEST
Julien Flament 1 , Maria-Angeles Carrillo-de Sauvage 2,3 , Julien Valette 2,3 , and Carole Escartin 2,3
1
U986 Inserm, MIRCen - CEA/Inserm, Fontenay-aux-Roses,
France,
2
CEA-MIRCen,
Fontenay-aux-Roses, France,
3
CNRS
URA 2210, Fontenay-aux-Roses, France
This study describes the possibility to image spatial
extension of astrocyte reactivity using gluCEST. A model
of selective astrocyte activation was used by
overexpression of the cytokine ciliary neurotrophic
factor (CNTF) in rat striatum. The model was first
characterized by NMR spectroscopy, showing a decrease of
glutamate (18%, n=9). GluCEST images were acquired on 5
rats and showed decrease of MTRasym reflecting glutamate
variation. Interestingly, the area of lower gluCEST
contrast matched well with the area containing activated
astrocytes (vimentin positive area in postmortem
studies). These results suggest that glutamate decrease
could be a surrogate marker of astrocyte reactivity.
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