Meeting Banner
Abstract #0757

Prior feeding of fat modulates the cortical response to fat in the mouth in humans

Sally Eldeghaidy 1,2 , Luca Marciani 3 , Joanne Hort 4 , Tracey Hollowood 4 , Gulzar Singh 5 , Debbie Bush 6 , Tim Foster 7 , Andy J. Taylor 4 , Johanneke Busch 8 , Robin C. Spiller 3 , Penny A. Gowland 2 , and Susan T. Francis 2

1 Department of Physics, Faculty of Science, Suez Canal University, Ismailia, Egypt, 2 Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, United Kingdom, 3 Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom, 4 Flavour Research Group, Division of Food Sciences, University of Nottingham, Nottingham, United Kingdom, 5 School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom, 6 Division of Surgery, Queen's Medical Centre University Hospital, Nottingham, United Kingdom, 7 Division of Food Sciences, University of Nottingham, Nottingham, United Kingdom, 8 Unilever Food and Health Research Institute, Unilever R&D, Vlaardingen, Netherlands

We investigated the modulation of BOLD responses to fat and control samples following prior feeding of a fat and water meal. The BOLD response in the anterior insula following consumption of the fat meal was suppressed compared to the water meal, with an increased rate of habituation to samples. Significant habituation was also seen in the amygdala, mid- and posterior insula. A decrease in reward and oral somatosensory activity was seen with increasing CCK and fullness values. These changes were found to be associated with a baseline reduction in CBF in the hypothalamus, thalamus and insula following the fat meal.

This abstract and the presentation materials are available to members only; a login is required.

Join Here