Abstract #0757
Prior feeding of fat modulates the cortical response to fat in the mouth in humans
Sally Eldeghaidy 1,2 , Luca Marciani 3 , Joanne Hort 4 , Tracey Hollowood 4 , Gulzar Singh 5 , Debbie Bush 6 , Tim Foster 7 , Andy J. Taylor 4 , Johanneke Busch 8 , Robin C. Spiller 3 , Penny A. Gowland 2 , and Susan T. Francis 2
1
Department of Physics, Faculty of Science,
Suez Canal University, Ismailia, Egypt,
2
Sir
Peter Mansfield Magnetic Resonance Centre, University of
Nottingham, Nottingham, United Kingdom,
3
Nottingham
Digestive Diseases Centre, University of Nottingham,
Nottingham, United Kingdom,
4
Flavour
Research Group, Division of Food Sciences, University of
Nottingham, Nottingham, United Kingdom,
5
School
of Biomedical Sciences, University of Nottingham,
Nottingham, United Kingdom,
6
Division
of Surgery, Queen's Medical Centre University Hospital,
Nottingham, United Kingdom,
7
Division
of Food Sciences, University of Nottingham, Nottingham,
United Kingdom,
8
Unilever
Food and Health Research Institute, Unilever R&D,
Vlaardingen, Netherlands
We investigated the modulation of BOLD responses to fat
and control samples following prior feeding of a fat and
water meal. The BOLD response in the anterior insula
following consumption of the fat meal was suppressed
compared to the water meal, with an increased rate of
habituation to samples. Significant habituation was also
seen in the amygdala, mid- and posterior insula. A
decrease in reward and oral somatosensory activity was
seen with increasing CCK and fullness values. These
changes were found to be associated with a baseline
reduction in CBF in the hypothalamus, thalamus and
insula following the fat meal.
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