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Abstract #0756

Dynamic modelling of layer specific cortical temperature for quantitative fMRI

Anna Gaglianese 1,2 , Peter Herman 1 , Daniel Coman 1 , Pietro Pietrini 2,3 , and Fahmeed Hyder 1,4

1 Department of Diagnostic Radiology - Magnetic Resonance Research Center, School of Medicine, Yale University, New Haven, CT, United States, 2 Laboratory of Clinical Biochemistry and Molecular Biology, Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy, 3 Clinical Psychology Branch, Pisa University Hospital, Pisa, Italy, 4 3Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT, United States

Characterizing the relationship between neurovascular and neurometabolic changes that occurs in the brain is crucial for fMRI measurements. Here, we developed a model that relates changes in temperature in space and time to layer specific variations of CBF, CBV and BOLD acquired with differente tecniques and CMR 02 measured by calibrated MRI, under rest and stimulation. We estimated and measured temperature changes nearly 0.1 C in the middle/lower layers in agreement with a tighter coupling between CBF and CMR 02 during stimulation. Temperature mapping and fMRI measurements may provide an useful tool to measure metabolic and hemodynamic variations in the brain.

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