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Abstract #0696

Age Dependence of the Metabolite Diffusion Tensor in Human Brain using Proton-Echo-Planar-Spectroscopic-Imaging

Alec Landow 1 , Elena Ackley 2 , Stephen R. Dager 3 , Dennis Shaw 3,4 , Mindy Dixon 4 , and Stefan Posse 1,2

1 Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM, United States, 2 Department of Neurology, University of New Mexico, Albuquerque, NM, United States, 3 Department of Radiology, University of Washington, Seattle, WA, United States, 4 Seattle Children's Hospital, Seattle, WA, United States

Diffusion tensor spectroscopic imaging (DTSI) in human brain provides intracellular markers for studying axonal development. DTSI was implemented at 3 Tesla using cardiac gated proton-echo-planar-spectroscopic-imaging (PEPSI). Movement-related phase and amplitude errors were corrected using spatially localized navigators. Data were acquired in 6 healthy volunteers (age range: 3 months 58 years) using 1-4.5 cc voxel size, bmax = 1734 s/mm2, and 6 gradient directions. The apparent diffusion coefficients of Cho, Cr and NAA in a 3-month old subject were significantly higher and the fractional anisotropy values were lower than those in the adults, consistent with studies of water diffusion.

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