Abstract #0697
Lower glutathione (GSH) concentration in the posterior cingulate cortex of healthy human elders measured at 7 T
Malgorzata Marjanska 1 and Melissa Terpstra 1
1
Center for Magnetic Resonance Research and
Department of Radiology, University of Minnesota,
Minneapolis, MN, United States
Oxidative stress occurs at an early stage of age related
cognitive decline. Ascorbate (Asc, vitamin C) and
glutathione (GSH) are key contributors to the
antioxidant network. Although lower
1
H
MRS GSH signal has been measured in the occipital cortex
(OCC) of an elder cohort, that finding could have been
confounded by differing transverse relaxation (
T
2
).
The purpose of this work was to utilize short echo time
1
H
MRS to overcome confounding by age associated difference
in
T
2
to
quantify GSH concentration in the aging brain in OCC and
posterior cingulate cortex (PCC, pertinent to the
pathology of Alzheimers disease).
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
