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Abstract #0695

An Investigation of Microstructural Tissue Damage in Systemic Lupus Erythematosus (SLE) with Neurological and Psychiatric Symptoms using Diffusion Weighted Spectroscopy (DWS) at 7T

Ece Ercan 1 , Emily T. Wood 2,3 , Mark van Buchem 4 , Andrew G. Webb 1 , and Itamar Ronen 1

1 C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2 NINDS, National Institutes of Health, Bethesda, Maryland, United States, 3 Dept of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4 Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Conventional MRI from SLE patients with neurological and psychiatric symptoms (SLEwNP) frequently appear normal and fail to explain the clinical symptoms, making the diagnostic procedure rather difficult and restricted to per exclusionem. Here we utilize DWS of brain metabolites in normal appearing white matter in the CC to investigate the tissue microstructural correlate of SLEwNP for the first time. The results suggest a disruption of astrocytic structure or physiology, which is in line with the inflammatory nature of the disease and show that ADC(tCho) may potentially become a biomarker for SLEwNP.

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