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Abstract #0692

Longitudinal monitoring of metabolic alterations in cuprizone mouse model of Multiple Sclerosis using 1 H magnetic resonance spectroscopy

Jasmien Orije 1 , Firat Kara 1 , Caroline Guglielmetti 1 , Jelle Praet 1 , Marleen Verhoye 1 , Peter Ponsaerts 2 , and Annemie Van der Linden 1

1 Bio-Imaging Lab, University of Antwerp, Wilrijk, Antwerp, Belgium, 2 Laboratory of Experimental Hematology, University of Antwerp, Wilrijk, Antwerp, Belgium

In this study, we employed quantitative in vivo 1H MRS to longitudinally monitor metabolic changes in the corpus callosum of C57BL/6 mice receiving a 0.2% cuprizone supplemented diet. Significant alterations in N-acetylaspartate, glycerophosphorylcholine, taurine and macromolecules and lipids were observed in the early demyelination phase (week 4 and 6) in the cuprizone fed mice compared to control mice, fed with standard rodent chow. Six week after the cuprizone withdrawal, these metabolic changes were no longer present suggesting that metabolic changes observed with 1 H MRS reflect key pathological features, such as demyelination, inflammation and axonal injury, caused by the cuprizone treatment.

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