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Abstract #0693

Correlations between BOLD and neurochemical responses measured in the human visual cortex at 7T

Petr Bednarik 1,2 , Ivan Tkac 1 , Federico Giove 3,4 , Dinesh K Deelchand 1 , and Silvia Mangia 1

1 CMRR - Dept. of Radiology, University of Minnesota, Minneapolis, MN, United States, 2 CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic, 3 Magnetic Resonance for Brain Investigation Lab, Enrico Fermi Center, Roma, Italy, 4 Dipartimento di Fisica, Sapienza Universit di Roma, Roma, Italy

Functional magnetic resonance spectroscopy (fMRS) is able to measure very small changes of metabolite concentrations during visual stimulation. These changes are ascribed to increased energetic neuronal oxidative metabolism. The aim of the current study was to correlate the neurochemical responses measured by fMRS with the metabolic/hemodynamic responses measured by the BOLD effect. Significant correlation between BOLD-fMRI signals and glutamate concentration changes during visual stimulation was found. Additionally, higher baseline GABA concentration measured at baseline predicted lower BOLD responses.

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