Abstract #0691
Reduced intracellular mobility underlies manganese relaxivity in mouse brain in vivo : MRI at 2.35 and 9.4 T
Takashi Watanabe 1 , Jens Frahm 1 , and Thomas Michaelis 1
1
Biomedizinische NMR Forschungs GmbH am
Max-Planck-Institut fr biophysikalische Chemie,
Gttingen, Germany
One day after systemic administration of manganese,
increases of the longitudinal relaxation rate ∆R
1
in
several brain regions are significantly higher at 2.35 T
than at 9.4 T. In contrast, ∆R
1
after
intraventricular Gd-DTPA administration are not
significantly different. The pronounced field dependence
of manganese relaxivities indicates a reduced mobility
of manganese
in
vivo
by
confinement to a viscous fluid compartment and/or due to
macromolecular binding. This is further supported by a
slow release of manganese from nerve cells
post
mortem
, which occurs despite a high permeability of
damaged cellular membranes.
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