Abstract #0581
Domain Gauges: A Reference System for Multivariate Profiling of Brain fMRI Activation Patterns Induced by Psychoactive Drugs in Rats
Andreas Bruns 1 , Thomas Mueggler 1 , Basil Knnecke 1 , Cline Risterucci 1 , Joseph G. Wettstein 1 , and Markus von Kienlin 1
1
Neuroscience Discovery, F. Hoffmann-La Roche
Ltd, Basel, Switzerland
We present domain gauges as a set of multivariate
metrics to easily quantify and characterize, with only a
few numbers, drug-induced brain fMRI activation
patterns. The gauges have been calibrated based on
different classes (domains) of marketed or validated
reference drugs. Capitalizing on our in-house database
with an unprecedented wealth of standardized rat-brain
perfusion fMRI data, we exemplarily defined and applied
3 domain gauges to demonstrate that our approach
represents a valuable analytical tool to reveal
drug-related neuronal circuits and concisely assess
brain activation patterns, thereby facilitating compound
characterization and decision making in drug discovery.
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