Abstract #0580
Optogenetic control of hemodynamic response in rat somatosensory cortex - fMRI and optical study
Bistra Iordanova 1 , Alberto T Vazquez 1 , Alex Poplawsky 1 , Takashi Kozai 2 , Hiro Fukuda 1 , Matthew Murphy 1 , and Seong-Gi Kim 1,3
1
Dept. of Radiology, University of
Pittsburgh, Pittsburgh, PA, United States,
2
Dept.
of Bioengineering, University of Pittsburgh, Pittsburgh,
PA, United States,
3
Dept.
of Biological Sciences, Center for Neuroscience Imaging
Research, Suwon, Korea
We use optogenetic approach to modulate the activity of
the pyramidal cells in the primary somatosensory cortex.
We record hemoglobin-based optical intrinsic signal
(OIS) at different light activation parameters. We then
compare the OIS to blood oxygenated level dependent
(BOLD) fMRI activation.
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