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Abstract #0580

Optogenetic control of hemodynamic response in rat somatosensory cortex - fMRI and optical study

Bistra Iordanova 1 , Alberto T Vazquez 1 , Alex Poplawsky 1 , Takashi Kozai 2 , Hiro Fukuda 1 , Matthew Murphy 1 , and Seong-Gi Kim 1,3

1 Dept. of Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2 Dept. of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, 3 Dept. of Biological Sciences, Center for Neuroscience Imaging Research, Suwon, Korea

We use optogenetic approach to modulate the activity of the pyramidal cells in the primary somatosensory cortex. We record hemoglobin-based optical intrinsic signal (OIS) at different light activation parameters. We then compare the OIS to blood oxygenated level dependent (BOLD) fMRI activation.

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