Abstract #0582
Distinct BOLD fMRI Responses of Capsaicin-induced Thermal Sensation Reveal Pain-related Brain Activation in Non-Human Primate
Abu Bakar Ali Asad 1 , Stephanie Seah 1 , Richard Baumgartner 2 , Dai Feng 2 , Andres Jensen 1 , Brian Henry 1 , Andrea Houghton 3 , Jeffrey Evelhoch 4 , and Chih-Liang Chin 1
1
Translational Medicine Research Centre, MSD,
Singapore, Singapore,
2
Biometrics
Research, Biostatistics and Research Decision Sciences,
Merck & Co Inc, Rahway, New Jersey, United States,
3
Neuroscience,
Merck & Co Inc, West Point, Pennsylvania, United States,
4
Imaging,
Merck & Co Inc, West Point, Pennsylvania, United States
To bridge preclinical research and clinical
investigation, we established a capsaicin pain heat fMRI
model in non-human primate with heat/42 C stimuli. We
hypothesize potentiation in heat-induced cortical
activation in response to capsaicin application at the
forearm will highlight the pain matrix depicted in
human pain fMRI experiments. Our results indicate that
group comparisons of brain activation between pre- and
post-capsaicin application show significant increases in
BOLD signals at the frontal, cingulate, precentral and
postcentral gyrus, and cerebellum (paired t-test,
p<0.002, n=8). Our data provide insights into
differentiating brain regions involved with pain-like
responses or thermal sensation.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
