Abstract #0534
Brain high-energy phosphates and creatine kinase synthesis rate under graded isoflurane anesthesia: An in vivo 31 P Magnetization Transfer Study at 11.7 Tesla
Andrew Bresnen 1 and Timothy Q. Duong 1
1
UTHSCSA - Research Imaging Institute, San
Antonio, Tx, United States
The accelerated
31
P
Four Angle Saturation Transfer (FAST) technique was
implemented to evaluate the brain high-energy phosphates
and the forward CK synthesis rate under graded
isoflurane anesthesia. High field (11.7 Tesla) and a
small sensitive surface coil were used to improve
31
P
signal sensitivity. The major findings were: i) the
forward creatine kinase rate and the metabolic flux of
the rat brain were reliably measured, and ii) changing
isoflurane concentration from 1.2% to 2.0% did not
change the PCr and ATP concentrations, but significantly
decreased the forward creatine kinase synthesis rate and
the metabolic flux.
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