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Abstract #0535

In vivo 13 C MRS in the mouse brain at 14.1 T and metabolic flux quantification during infusion of [1,6- 13 C 2 ] Glucose

Marta Lai 1 , Bernard Lanz 1,2 , Carola Jaquelina del Carmen Romero 1,3 , Cristina Cudalbu 3 , and Rolf Gruetter 1,4

1 Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 2 Department of Radiology, University of Lausanne, Lausanne, Switzerland, 3 Centre dImagerie Biomedicale, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 4 Departments of Radiology, University of Lausanne and Geneva, Switzerland

13 C MRS in conjunction with [1,6- 13 C] Glucose infusion is a powerful tool to access in vivo brain energy metabolism and neurotransmission. Unfortunately, due to the intrinsic low sensitivity of 13 C detection, acquisitions are commonly limited to fairly big volumes restricting its in vivo application in the rat brain. With our present work we want to overcome these limitations proving the feasibility of 13 C MRS in the mouse brain at 14.1 Tesla. Successful completion of 10-minutes spectra acquisition in the mouse brain allows metabolic fluxes quantification and opens the possibility to study a wide range of transgenic mice models in vivo.

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