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Abstract #0500

Flow Characteristics in Bicuspid Aortic Valve Relatives compared to normal controls using 4D flow MRI

Susanne Schnell 1 , Alex J Barker 1 , Pegah Entezari 1 , A Reza Hornamand 1 , Pim van Ooij 1 , S Chris Malaisrie 2 , Patrick M McCarthy 2 , Jeremy Collins 1 , James C Carr 1 , and Michael Markl 1,3

1 Radiology, Northwestern University, Chicago, Illinois, United States, 2 Surgery, Cardiac Surgery Division, Northwestern University, Chicago, Illinois, United States, 3 Biomedical Engineering, Northwestern University, Evanston, Illinois, United States

We evaluated flow dynamics, aorta diameter and geometry in relatives with a family member expressing a bicuspid aortic valve (BAV) and compared results to normal volunteers using contrast enhanced cardiac MRI and 4D flow MRI. The findings demonstrate subtle but significant differences in aortic hemodynamics in BAV relatives compared to age-matched normal controls. Of note, BAV relatives expressed more cubic shaped aortas, which may explain the observed differences. In fact, the significant higher vortex flow in the BAV relatives in the ascending and descending, as well as the significantly lower WSS was related to cubic aortic shape.

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