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Abstract #0501

Quantitative assessment of splenic hemodynamics at 4D flow MRI in the evaluation of thrombocytopenia: A pilot study in cirrhotic patients with portal hypertension

Jad Bou Ayache 1 , Zoran Stankovic 1 , Edouard Semaan 1 , James C Carr 1 , Michael Markl 1 , and Jeremy D Collins 1

1 Radiology Department, Feinberg School of Medicine, Chicago, Illinois, United States

Hypersplenism is a well-recognized, treatable cause of thrombocytopenia. However, the underlying flow disturbances contributing to platelet sequestration by the spleen are unknown. Liver donation, hematologic malignancy and liver cirrhosis predisposes to splenomegaly associated with various degrees of thrombocytopenia. We hypothesized that differences in splenic hemodynamics could explain the increased filtration effect independent of splenic size. 4D flow MRI was performed in patients with liver disease and healthy volunteers, correlating indexed splenic arterial and venous flow with platelet counts. Our feasibility study demonstrates significant differences in indexed splenic hemodynamics between patients with and without thrombocytopenia.

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