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Abstract #0499

Thoracic Aorta 3D Wall Shear Stress as a Marker of Bicuspid Aortic Valve Disease in Pediatric Patients

Bradley D Allen 1 , Pim van Ooij 1 , Alex J. Barker 1 , Maria Carr 1 , Maya Gabbour 2 , Michael Markl 1,3 , Cynthia K Rigsby 2 , and Joshua D Robinson 4

1 Department of Radiology, Northwestern University, Chicago, IL, United States, 2 Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 3 Department of Biomedical Engineering, Northwestern University, Chicago, IL, United States, 4 Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States

Pediatric bicuspid aortic valve (BAV) patients are not at increased risk of cardiovascular complications during childhood, but often require surgical management of their disease to limit progressive ascending aorta (AAo) dilation and reduce their risk of events in adulthood. Wall shear stress (WSS) has been shown to lead to vascular remodeling and may be the hemodynamic driver of progressive AAo dilation in these patient. In this study, 4D flow MRI was used to non-invasively quantify 3D WSS in the aorta of pediatric BAV patients, and WSS was found to correlate with AAo diameter and peak velocity.

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