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Abstract #0479

3D GABA imaging with high spatial resolution at 3T using a navigated MEGA-LASER MRSI sequence

Wolfgang Bogner 1 , Borjan Gagoski 2 , Aaron T Hess 3 , Bernhard Strasser 1 , Himanshu Bhat 4 , Dylan Tisdall 5 , Andre J.W. van der Kouwe 5 , Ellen Grant 2 , Siegfried Trattnig 1 , Bruce Rosen 5 , and Ovidiu C Andronesi 5

1 High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Vienna, Austria, 2 Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, United States, 3 Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom, 4 Siemens Healthcare, Charlestown, United States, 5 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States

GABA, the major inhibitory neurotransmitters, is difficult to detect. Single-voxel MEscher-GArwood (MEGA) PRESS editing MRS is the most popular technique for non-invasive detection of GABA, but it has several limitations: MEGA editing is a subtraction technique and, therefore, prone to scanner instabilities and motion artifacts. Chemical shift displacement errors (CSDE) in PRESS reduce editing efficiency. Single-voxel localization does not allow the characterization of spatial concentration differences. Therefore, our study introduces a robust MEGA-editing 3D-CSI sequence for 3T that uses LASER localization to eliminate CSDE; spiral encoding to accelerate acquisition; and real-time motion-/B0-correction with selective data reacquisition to eliminate subtraction artifacts.

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