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Abstract #0478

Regional variations of GABA, glutamate, glutamine and NAAG in the human brain, as measured by 1H MRS at 7T in vivo

Changho Choi 1 , Sandeep Ganji 1 , Zhongxu An 1 , and Akshay Madan 1

1 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, United States

We report regional variations in metabolite levels in healthy human brain, focusing on GABA, glutamate, glutamine, and N-acetyl-aspartyl-glutamate. A GABA-tailored PRESS sequence (TE = 92 ms) was used, at 7T, to measure the metabolites in gray matter (GM) and white matter (WM) dominant regions in the frontal and occipital brain in 9 healthy volunteers. Metabolite levels in pure GM and WM were obtained with linear regression of metabolite estimates vs. fractional GM contents. The result indicated that the concentrations of many metabolites are significantly different between frontal and occipital brain as well as between GM and WM.

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