Meeting Banner
Abstract #0480

Preliminary Study of Cerebral NAD Metabolism and Redox State in Parkinsons Patients

Xiao-Hong Zhu 1 , Byeong-Yeul Lee 1 , Susan Rolandelli 2 , Ming Lu 1 , Paul Tuite 2 , and Wei Chen 1

1 CMRR, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States, 2 Department of Neurology, University of Minnesota Medical School, MN, United States

Energy failure from mitochondrial dysfunction has been proposed as a central mechanism leading to neuronal death in a range of neurodegenerative diseases. However, it is difficult to evaluate the link between abnormal energetics and impaired mitochondrial functions associated with neurodegeneration in living human brain. Recently a new high-field in vivo 31 P MRS approach has been developed and its capability for non-invasively assessing the intracellular nicotinamide adenine dinucleotide (NAD) contents and its redox ratio has been demonstrated in healthy human brain at 7T. In the present study, we applied this newly developed method for quantitative assessment and comparison of NAD redox state in Parkinsons disease (PD) patients and matched controls. The preliminary findings demonstrated abnormal cerebral energy metabolism associated with PD and the potential influences of gender in the disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here