Theoretical Framework for MR Fingerprinting with ASL: Simultaneous Quantification of CBF, Transit Time, and T 1
Katherine L. Wright 1 , Dan Ma 1 , Yun Jiang 1 , Vikas Gulani 1,2 , Mark A. Griswold 1,2 , and Luis Hernandez-Garcia 3
Biomedical Engineering, Case Western Reserve
University, Cleveland, Ohio, United States,
Case Western Reserve University, Cleveland, Ohio, United
fMRI Lab, University of Michigan, Ann Arbor, Michigan,
The purpose of this study is to explore the use of the
MR Fingerprinting framework for ASL-based parameter
quantification. MRF has recently been introduced as an
accurate and efficient approach for simultaneous
quantification of multiple physical or physiological
parameters. Here we show how MRF can be extended to
quantitation of ASL perfusion-related parameters,
including cerebral blood flow (CBF) and transit time.
The goal of this work is to develop a theoretical
framework that could overcome limitations in traditional
ASL by providing a new approach to acquisition of ASL
data and estimation of perfusion parameters.
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