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Abstract #0417

Theoretical Framework for MR Fingerprinting with ASL: Simultaneous Quantification of CBF, Transit Time, and T 1

Katherine L. Wright 1 , Dan Ma 1 , Yun Jiang 1 , Vikas Gulani 1,2 , Mark A. Griswold 1,2 , and Luis Hernandez-Garcia 3

1 Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States, 2 Radiology, Case Western Reserve University, Cleveland, Ohio, United States, 3 UM fMRI Lab, University of Michigan, Ann Arbor, Michigan, United States

The purpose of this study is to explore the use of the MR Fingerprinting framework for ASL-based parameter quantification. MRF has recently been introduced as an accurate and efficient approach for simultaneous quantification of multiple physical or physiological parameters. Here we show how MRF can be extended to quantitation of ASL perfusion-related parameters, including cerebral blood flow (CBF) and transit time. The goal of this work is to develop a theoretical framework that could overcome limitations in traditional ASL by providing a new approach to acquisition of ASL data and estimation of perfusion parameters.

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