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Abstract #0416

Model-Free Spectral Fat Analysis Based on Ultra-Dense Echo Sampling Using a Singular Value Decomposition Matrix Pencil Method

Xeni Deligianni 1 and Oliver Bieri 1

1 Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, NA, Switzerland

Assessing tissue fat fraction and composition is of increased clinical interest as a biomarker for various muscle and liver diseases. Here, we propose a new method to achieve an ultra-dense echo sampling in the tens of microseconds regime within clinically feasible scan times. This allows a model-free signal time course analysis based on a singular value decomposition matrix pencil method to resolve the spectral components of fat. The effect of the echo spacing and the pre-set of signal spectral components is analyzed. Four fat peaks are being resolved and the results are in agreement with literature. Reducing the preset signal components results in an underestimation of the fat percentage.

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