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Abstract #0382

Dynamic fPET/fMRI of the human visual system

Marjorie Villien 1 , Joseph B. Mandeville 1 , Hsiao-Ying Wey 1 , Ciprian Catana 1 , Jonathan R. Polimeni 1 , Christin Y. Sander 2 , Nicole R. Zrcher 1 , Daniel B. Chonde 1 , Joanna S. Fowler 3 , Bruce R. Rosen 1 , and Jacob M. Hooker 1

1 Martinos Center for Biomedical Imaging, MGH/Harvard Medical School, Boston, MA, United States, 2 2Department of Electrical Engineering and Computer Science, MIT, Boston, MA, United States, 3 Biosciences Department, Brookhaven National Laboratory, Upton, NY, United States

Brain mapping of task-associated changes in metabolism with PET has been accomplished in the past by subtracting scans acquired during two distinct static states. Here we show that PET can provide truly dynamic information on cerebral metabolism using concepts common to fMRI. Using 2-[18F]-fluoro-deoxyglucose (FDG), we show that quantitative glucose utilization changes during multiple visual stimuli can be determined using FDG constant infusion in a single-imaging experiment. This functional PET (fPET-FDG) method can be accomplished simultaneously with fMRI (BOLD and ASL) and thus enables the first direct comparisons in time, space and magnitude of glucose utilization, hemodynamics and oxygen consumption.

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