Brain connectivity mapping based on Positron Emission Tomography (PET) in comparison to fMRI using combined PET/MR
Hans F Wehrl 1 , Mosaddek Hossain 1 , Michael Walker 1 , Gerald Reischl 1 , Petros Martirosian 2 , Fritz Schick 2 , and Bernd J Pichler 1
Werner Siemens Imaging Center, Department of
Preclinical Imaging and Radiopharmacy, University of
Tuebingen, Tuebingen, Germany,
on Experimental Radiology of Dept. of Diagnostic and
Interventional Radiology, University of Tuebingen,
Brain connectivity is mainly derived from fMRI data.
Here we present an approach to visualize functional and
metabolic networks in the rat brain using combined PET
and MR imaging. Three different PET tracers, mapping
glucose, perfusion and serotonin transporter
contributions to functional connectivity are compared
with fMRI. Our results reveal that fundamental
information about functional and metabolic brain
networks is encoded in dynamic and static PET data. This
opens the arena for quantitative PET based functional
connectivity methods that can be complemented with fMRI.
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