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Abstract #0383

Brain connectivity mapping based on Positron Emission Tomography (PET) in comparison to fMRI using combined PET/MR

Hans F Wehrl 1 , Mosaddek Hossain 1 , Michael Walker 1 , Gerald Reischl 1 , Petros Martirosian 2 , Fritz Schick 2 , and Bernd J Pichler 1

1 Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany, 2 Section on Experimental Radiology of Dept. of Diagnostic and Interventional Radiology, University of Tuebingen, Tuebingen, Germany

Brain connectivity is mainly derived from fMRI data. Here we present an approach to visualize functional and metabolic networks in the rat brain using combined PET and MR imaging. Three different PET tracers, mapping glucose, perfusion and serotonin transporter contributions to functional connectivity are compared with fMRI. Our results reveal that fundamental information about functional and metabolic brain networks is encoded in dynamic and static PET data. This opens the arena for quantitative PET based functional connectivity methods that can be complemented with fMRI.

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