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Abstract #0381

Internalization of dopamine receptors imaged in vivo by simultaneous PET/fMRI

Christin Y. Sander 1,2 , Jacob M. Hooker 1 , Ciprian Catana 1 , Bruce R. Rosen 1,3 , and Joseph B. Mandeville 1

1 A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 2 Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States, 3 Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States

Receptor internalization is an adaptation mechanism shown to occur in response to large agonist doses. To date, there has not been a method for detecting internalization in vivo, although it may affect functional imaging signals. In this study, we use simultaneous PET/fMR imaging and graded doses of a D2 agonist in order to investigate D2 receptor internalization. We propose a model that combines fMRI timecourses with dynamic receptor occupancies measured by PET to derive an in vivo index of dopamine receptor internalization non-invasively.

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