Abstract #0381
Internalization of dopamine receptors imaged in vivo by simultaneous PET/fMRI
Christin Y. Sander 1,2 , Jacob M. Hooker 1 , Ciprian Catana 1 , Bruce R. Rosen 1,3 , and Joseph B. Mandeville 1
1
A. A. Martinos Center for Biomedical
Imaging, Massachusetts General Hospital, Harvard Medical
School, Charlestown, MA, United States,
2
Electrical
Engineering, Massachusetts Institute of Technology,
Cambridge, MA, United States,
3
Health
Sciences and Technology, Harvard-MIT, Cambridge, MA,
United States
Receptor internalization is an adaptation mechanism
shown to occur in response to large agonist doses. To
date, there has not been a method for detecting
internalization in vivo, although it may affect
functional imaging signals. In this study, we use
simultaneous PET/fMR imaging and graded doses of a D2
agonist in order to investigate D2 receptor
internalization. We propose a model that combines fMRI
timecourses with dynamic receptor occupancies measured
by PET to derive an in vivo index of dopamine receptor
internalization non-invasively.
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