Meeting Banner
Abstract #0193

Targeted MRI In Vivo by Hyperpolarized Silicon Nanoparticles

Jingzhe Hu 1 , Maja Cassidy 2 , Nicholas Whiting 1 , Pamela Constantinou 3 , Niki Zacharias Millward 1 , David Volk 4 , David Gorenstein 4 , Daniel Carson 3 , Charles Marcus 5 , and Pratip Bhattacharya 1

1 Cancer Systems Imaging, The University of Texas, MD Anderson Cancer Center, Houston, TX, United States, 2 Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands, 3 Biochemistry and Cell Biology, Rice University, Houston, TX, United States, 4 Institute of Molecular Medicine and Department of NanoMedicine and Biomedical Engineering, The University of Texas Health Science Center at Houston, Houston, TX, United States, 5 Center for Quantum Devices, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark

Nanomedicine is an emerging field that offers great promise in the development of non-invasive strategies for the diagnosis and treatment of disease. Hyperpolarized silicon nanoparticles are one such material that has emerged as a platform technology for targeting that may suit a wide range of potential applications. They can be easily surface functionalized, are biocompatible and biodegradable and has opened up the possibility of performing in vivo targeted MRI in real time with over 10,000 fold sensitivity enhancement via dynamic nuclear polarization (DNP).

This abstract and the presentation materials are available to members only; a login is required.

Join Here