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Abstract #0192

Manganese(II)-Block Copolymer Complexes and Their Use for MRI of Biological Processes

Nikorn Pothayee 1 , Der-Yow Chen 1 , Maria Aronovo 2 , Chunqi Qian 1 , Richard Leapman 2 , and Alan Koretsky 1

1 Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD, United States, 2 Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, NIH, Bethesda, MD, United States

In this work,we describe a one-pot and aqueous-based preparation of paramagnetic metal ion-block copolymer complexes for potential use as MRIcontrast agent. The pH-sensitive nature of soft particles was exploited in response to neuronal uptake and subsequent transport of Mn ions, which can be visualized by MRI.

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