Abstract #0192
Manganese(II)-Block Copolymer Complexes and Their Use for MRI of Biological Processes
Nikorn Pothayee 1 , Der-Yow Chen 1 , Maria Aronovo 2 , Chunqi Qian 1 , Richard Leapman 2 , and Alan Koretsky 1
1
Laboratory of Functional and Molecular
Imaging, NINDS, NIH, Bethesda, MD, United States,
2
Laboratory
of Cellular Imaging and Macromolecular Biophysics, NIBIB,
NIH, Bethesda, MD, United States
In this work,we describe a one-pot and aqueous-based
preparation of paramagnetic metal ion-block copolymer
complexes for potential use as MRIcontrast agent. The
pH-sensitive nature of soft particles was exploited in
response to neuronal uptake and subsequent transport of
Mn ions, which can be visualized by MRI.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
