Abstract #0191
Monitoring the efficacy and retention of collagen I-Matrigel for treating myocardial infarction
Marloes Marteijn 1 , Carlijn CV Bouten 2 , Klaas Nicolay 1 , and Gustav J Strijkers 1
1
Biomedical NMR, Department of Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Netherlands,
2
Soft
Tissue Biomechanics & Tissue Engineering, Department of
Biomedical Engineering, Eindhoven University of
Technology, Eindhoven, Netherlands
Hydrogels have the potential to improve cardiac function
after myocardial infarction (MI). Furthermore, hydrogels
can be used to improve cell engraftment in case of stem
cell therapy post-MI. In this study, we investigated the
efficacy and retention of collagen I-Matrigel after
intramyocardial injection post-MI in a mouse model by
applying multiple in vivo cardiac MRI techniques. Here,
we show that collagen I-Matrigel treatment resulted in a
temporary increased cardiac function post-MI, but also
provoked an enhanced edema and/or inflammatory response
in the cardiac tissue surrounding the collagen I-Matrigel
as indicated by T2-mapping as well as by histology.
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