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Abstract #0190

Cardiac MR Elastography: Estimation of myocardial stiffness throughout cardiac cycle as a function of age

Peter A Wassenaar 1 , Chethanya N Eleswarpu 1 , Richard D White 1 , and Arunark Kolipaka 1

1 Radiology, The Ohio State University, Columbus, Ohio, United States

Myocardial stiffness has been a significant biomarker for various cardiovascular disease processes, such as myocardial infarction, hypertension, diastolic dysfunction and tissue rejection in heart transplant patients. Pressure/volume based techniques are commonly used to measure left ventricular chamber stiffness, but are limited to global measurements, are invasive, and do not provide true intrinsic properties of the myocardium. Recently, Cardiac MR Elastography was used to estimate stiffness of the myocardium. In this study, a retrogated, multi-phase MRE sequence was developed and used to measure LV myocardial stiffness across the cardiac cycle as a function of age in healthy subjects.

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