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Abstract #0163

Restoration of Interhemispheric Resting-state fMRI Connectivity after Patrial Corpus Callosotomy via Intrahemispheric Reorganization

Iris Y Zhou 1,2 , Mengye Lyu 1,2 , Russell W Chan 1,2 , Y X Liang 3 , Adrian Tsang 1,2 , K F So 3 , and Ed X Wu 1,2

1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, 3 Department of Anatomy, The University of Hong Kong, Hong Kong SAR, China

Resting-state fMRI (rsfMRI) has shown potentials in revealing the functional plasticity after brain injury and training. Our previous study on a rat model of corpus callosotomy has demonstrated that disrupted rsfMRI connectivity can be partially restored atop the axonal connections as indispensable foundation. In this study, we further investigated the rsfMRI network reorganization after complete and partial callosotomy, aiming to identify the rewiring mechanism and topological alterations of rsfMRI networks if any. The results showed the restoration of disrupted interhemispheric connectivity may stem from the remodeling of intrahemispheric rsfMRI connectivity together with the remaining interhemispheric axonal pathways.

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