Abstract #0162
Optogenetic manipulation of VTA dopaminergic neurons and global patterns of functional neural connectivity
Heather K. Decot 1 , Yen-Yu Ian Shih 2,3 , Wei Gao 2,4 , Pranish Kantak 5 , Ian Jiang 6 , Karl Deisseroth 7 , Ilana B. Witten 8 , and Garret D. Stuber 1,9
1
Curriculum in Neurobiology, University of
North Carolina at Chapel Hill, Chapel Hill, NC, United
States,
2
Biomedical
Research Imaging Center, University of North Carolina at
Chapel Hill, NC, United States,
3
Neurology,
University of North Carolina at Chapel Hill, NC, United
States,
4
Radiology,
University of North Carolina at Chapel Hill, NC, United
States,
5
Psychiatry,
University of North Carolina at Chapel Hill, North
Carolina, United States,
6
University
of North Carolina at Chapel Hill, NC, United States,
7
Bioengineering,
Stanford University, CA, United States,
8
Psychology,
Princeton University, Princeton, NJ, United States,
9
Psychiatry,
University of North Carolina at Chapel Hill, NC, United
States
Here, we coupled optogenetic stimulation techniques with
functional magnetic resonance imaging (fMRI) technology
in an in vivo rat model to selectively activate
dopaminergic neurons within the ventral tegmental area (VTA).
This study demonstrates that transient optogenetic
activation of DA neurons within the midbrain causes
significant regional CBV increases in downstream targets
of the VTA including the dorsal and ventral striatum.
Future directions include exploring how DA
neuromodulation promotes or suppresses functional
connectivity within the intact brain.
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