Abstract #0164
Spontaneous activity in the delta band drives the resting state MRI (rsMRI) signal: A combined rsMRI and electrophysiological study in rat whisker barrel cortex
Hanbing Lu 1 , William Rea 1 , Leiming Wang 1 , Elliot A Stein 1 , and Yihong Yang 1
1
National Institute on Drug Abuse, Baltimore,
Maryland, United States
The physiological basis of resting state MRI (rsMRI)
signal remains poorly understood. Several lines of
evidence suggest the important role of spontaneous slow
and infraslow EEG oscillation underlying the
low-frequency BOLD fluctuations; Contrasting hypotheses
emphasize the roles of higher frequency (gamma)
activity. One approach to disentangle the relationship
between electrophysiological and rsMRI signal is to
investigate how evoked responses interact with ongoing
spontaneous brain activity. We employ a whisker barrel
cortex stimulation model to investigate this question.
Our findings support the view that spontaneous activity
in the delta band drives the rsMRI signal as manifested
in functional connectivity.
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