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Abstract #0158

Impaired synaptic pruning produces long-range functional connectivity deficits in the mouse brain

Alessandro Gozzi 1 , Yang Zhan 2 , Rosa C Paolicelli 2 , Francesco Sforazzini 1 , Alexei Vyssotski 3 , Angelo Bifone 1 , and Cornelius Gross 2

1 MRI Laboratory, Istituto Italiano di Tecnologia, Centre for Neuroscience and Cognitive Sciences, Rovereto, Trento, Italy, 2 Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy, Roma, Italy, 3 Institute of Neuroinformatics, University of Zrich and Swiss Federal Institute of Technology (ETH), Zurich, Zurich, Switzerland

Human fMRI studies have revealed impaired long-range functional connectivity in neuro-developmental disorders such as schizophrenia and autism. Deficits in the postnatal elimination of synapses (i.e. pruning), are thought to play an etiopathological role in these conditions. We used resting-state fMRI (rsfMRI) to test whether impaired synaptic maturation is sufficient to induce functional connectivity deficits. We found that Cx3cr1-KO mice, a line characterised by marked deficits in synaptic pruning, exhibit reduced long-range rsfMRI and LFP coherence in fronto-hippocampal areas. These results demonstrate that disruption in synaptic pruning is sufficient to produce connectional deficits reminiscent of those observed in human neurodevelopmental disorders

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