Meeting Banner
Abstract #0159

GABAergic effect on resting-state functional connectivity

Fatima Nasrallah 1 , Kavita Kaur D/O Ranjit Singh 2 , Yeow Ling Yun 2 , and Kai-Hsiang Chuang 2

1 Clinical Imaging Research Center, Singapore, Singapore, Singapore, 2 Singapore Bioimaging Consortium, Singapore, Singapore, Singapore

To understand the neurotransmission basis of resting-state functional connectivity, BOLD and EEG were measured when GABAA receptor system was antagonized by bicuculline. We found that inhibition of the GABAergic system in the brain increases both neural activity and functional connectivity. EEG shows intact neurovascular coupling and increased beta and gamma oscillation at resting state. This supports the neural basis and the role of inhibitory system on functional connectivity.

This abstract and the presentation materials are available to members only; a login is required.

Join Here