Abstract #0157
Complex interplay between structural and functional brain connectivity in acallosal BTBR T+tf/J mice
Francesco Sforazzini 1 , Luca Dodero 2 , Alberto Galbusera 1 , Angelo Bifone 1 , and Alessandro Gozzi 1
1
MRI Laboratory, Istituto Italiano di
Tecnologia, Centre for Neuroscience and Cognitive
Sciences, Rovereto, Trento, Italy,
2
Pavis
Lab, Istituto Italiano di Tecnologia, Genova, Genova,
Italy
Iinvestigations in healthy humans have highlighted an
overall good correspondence between functional and
structural connectivity. However, recent studies
examining congenital or surgical alteration of the
corpus callosum have produced conflicting results that
challenge this view. Here we used high-resolution DTI
and fMRI to probe structural and functional brain
connectivity in BTBR mice, an acallosal strain widely
used to mimic autism-like symptoms. We provide evidence
of adaptive structural and functional cortico-cortical
connectivity together with the presence of severely
impaired antero-posterior and subcortical functional
correlations. Our results highlight a complex
region-dependent interplay between function and
structure in congenital acollosal brains.
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