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Abstract #0142

Gadoxetate-enhanced MRI in rats with liver cirrhosis: comparison between functional liver parameters obtained with deconvolution analysis and compartmental models as markers of hepatocyte transporter expression

Cline Giraudeau 1 , Jean-Luc Daire 1 , Matthieu Lagadec 1 , Sabrina Doblas 1 , Catherine Pastor 2 , and Bernard Van Beers 1

1 INSERM Centre de Recherche Biomdicale Bichat Beaujon,CRB3 U773, Universit Paris Diderot, Sorbonne Paris Cit, Clichy, France, 2 Laboratoire de Physiopathologie Hpatique et Imagerie Molculaire,Hpitaux Universitaires de Genve, Geneva, Switzerland

We have previously shown that the hepatic functional parameters (hepatic extraction fraction (HEF) and mean residence time (MRT)) obtained with deconvolution analysis at gadoxetate-enhanced MRI correlate with the expression of the oatp/mrp transporters in liver cirrhosis. The aim of this study was to assess if a multicompartmental model of hepatocytic transport gives further insight into the expression of the oatp/mrp transporters in liver cirrhosis. Both methods were evaluated in normal and cirrhotic rats through calculation of Akaike criteria and multiple regression analysis. The superiority of a multicompartmental relative to a deconvolution model remains here to be proven.

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