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Abstract #0143

R2* of water and fat in hepatic iron overload: implications for R2*-corrected fat quantification

Debra E. Horng 1,2 , Diego Hernando 1 , and Scott B. Reeder 1,2

1 Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Accurate fat quantification using chemical shift-encoded techniques requires correction for R2* (=1/T2*) decay. Correction for a common R2* for both fat and water (single-R2*) has been shown to be accurate for FF quantification in patients without iron overload. In this work, the accuracy of single-R2* correction is assessed in patients with iron overload. Fat-fraction and R2* were measured in 42 subjects at 1.5T and 3.0T, with both imaging and spectroscopy. The R2* of fat and water are very similar even in the presence of iron overload, showing that fat quantification with single-R2* correction is accurate even for patients with iron overload.

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