Abstract #0141
In-vivo evaluation of hepatic function using dynamic Gd-EOB-DTPA enhanced MRI with a dual-input one output two-compartment pharmacokinetics model
Jia Ning 1 , Sheng Xie 2 , Lei Wang 2 , Hua Guo 1 , Xihai Zhao 1 , Chun Yuan 1,3 , and Huijun Chen 1
1
Center for Biomedical Imaging Research &
Department of Biomedical Engineering, Tsinghua
University, Beijing, China,
2
Department
of Radiology, China-Japan Friendship Hospital, Beijing,
China,
3
Department
of radiology, University of Washington, Seattle, WA,
United States
Liver function is an important and sensitive indicator
for liver damage. In this study, we proposed a new
hemodynamic model to better describe the behavior of the
Gd-EOB-DTPA by adding a directly measured contrast
excretion term from hepatic vein. Validations with serum
liver functional parameters were carried out for the
proposed model and original model. Model parameters Ki
is found significantly correlated with the concentration
of preALB and ALB in serum. The proposed dual-input one
output two-compartment pharmacokinetics model for
dynamic Gd-EOB-DTPA enhanced liver MRI is capable of
localized liver function evaluation in-vivo.fibrosis can
envolve to cirrhosis and finally end up with hepatic
carcinoma. Various studies have shown that fibrosis of
level 1 and level 2 can be reversible [2], early
diagnosis of liver fibrosis is critical for treatment
and recovery. Dynamic contrast enhanced MR imaging is
one of the most powerful protocols to evaluate the
condition of liver. Gd-EOB-DTPA is a new type of
hepatocyte specific contrast agent [3] for liver
function evaluation. It has the advantages of specific
binding with hepatocytes, and excretion through the
hepatic vein, kidney and biliary. According to the
properties of this contrast agent, we propose a new
hemodynamics model to describe the perfusion of the
liver. It is supposed that the parameters of the model
can give an instruction of hepatic function and provide
useful information for diagnosis of liver fibrosis.
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